CHEMICAL CHARACTERIZATION OF A FAMILY OF BRAIN LIPIDS THAT INDUCE SLEEP

被引：546

作者：

CRAVATT, BF

PROSPEROGARCIA, O

SIUZDAK, G

GILULA, NB

HENRIKSEN, SJ

BOGER, DL

LERNER, RA

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA

[3] Scripps Res Inst, DEPT CELL BIOL, LA JOLLA, CA 92037 USA

来源：

SCIENCE | 1995年 / 268卷 / 5216期

关键词：

D O I：

10.1126/science.7770779

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results suggest that fatty acid primary amides may represent a previously unrecognized class of biological signaling molecules.

引用

页码：1506 / 1509

页数：4

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