P53 AND BCL-2 EXPRESSION IN HIGH-GRADE B-CELL LYMPHOMAS - CORRELATION WITH SURVIVAL-TIME

被引:162
作者
PIRIS, MA
PEZELLA, F
MARTINEZMONTERO, JC
ORRADRE, JL
VILLUENDAS, R
SANCHEZBEATO, M
CUENA, R
CRUZ, MA
MARTINEZ, B
GARRIDO, MC
GATTER, K
AIELLO, A
DELIA, D
GIARDINI, R
RILKE, F
机构
[1] HOSP VIRGEN SALUD,DEPT STAT,E-45004 TOLEDO,SPAIN
[2] HOSP VIRGEN SALUD,DEPT ONCOL,E-45004 TOLEDO,SPAIN
[3] JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL,OXFORD OX3 9DU,ENGLAND
[4] INST NAZL CURA STUDIO TUMORI,DIV ONCOL SPERIMENTALE A,I-20133 MILAN,ITALY
[5] JOHN RADCLIFFE HOSP,LEUKEMIA RES FUND IMMUNODIAGNOST UNIT,OXFORD OX3 9DU,ENGLAND
[6] INST NAZL CURA STUDIO TUMORI,DIV ANAT PATOL,I-20133 MILAN,ITALY
关键词
D O I
10.1038/bjc.1994.61
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B-cell high-grade lymphomas are heterogeneous in terms of histology, clinical presentation, treatment response and prognosis. As bcl-2 and p53 gene deregulations are frequencly involved in several types of lymphoid malignancies, we aimed our investigation at the study of the relation between bcl-2 and p53 expression and survival probability in a group of 119 patients with B-cell high-grade lymphoma. These were obtained from the Virgen de la Salud Hospital, Toledo, Spain (73 cases), John Radcliffe Hospital, Oxford, UK (31 cases), and the Istituto Nazionale dei Tumori, Milan, Italy (15 cases). The relation between bcl-2 protein expression and survival was small, depending on the primary localisation of the tumour (in lymph node of mucosae), and lacked a significant correlation with overall survival. In contrast with this, p53 expression was related to survival probability in our series, this relation being both significant and independent of histological diagnosis. p53-positive patients showed a sudden decrease in life expectancy in the first months after diagnosis. Multivariant regression analysis confirmed that the only parameters significantly related with survival were extranodal origin, which is associated with a better prognosis, and p53 expression, which indicates a poor prognosis. Simultaneous expression of bcl-2 and p53 was associated with a poorer prognosis than p53 alone. This is particularly significant for large B-cell lymphomas presenting in lymph nodes. The cumulative poor effect of both p53 and bcl-2 in large B-cell lymphomas, which is more significant in nodal tumours, could confirm the existence of a multistep genetic deregulation in non-Hodgkin's lymphoma. This indicates that the genetic mechanisms controlling apoptosis and their disregulation are critical steps in the progression of lymphomas.
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页码:337 / 341
页数:5
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