ENHANCEMENT BY TNF-ALPHA OF REACTIVATION AND REPLICATION OF LATENT HERPES-SIMPLEX VIRUS FROM TRIGEMINAL GANGLIA OF MICE

被引：19

作者：

WALEV, I ^{[1
]}

PODLECH, J ^{[1
]}

FALKE, D ^{[1
]}

机构：

[1] UNIV MAINZ,INST MED MICROBIOL,DIV EXPTL VIROL,D-55101 MAINZ,GERMANY

来源：

ARCHIVES OF VIROLOGY | 1995年 / 140卷 / 06期

关键词：

D O I：

10.1007/BF01315409

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influence of tumor-necrosis-factor-alpha (TNF-alpha), granulocytemacrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) and IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-alpha and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivation frequency and replication of HSV. Interferon alpha/beta (IFN alpha/beta)prevented reactivation and replication.

引用

页码：987 / 992

页数：6

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