PLATELET-ADHESION RECEPTORS

被引:37
作者
WILLIAMS, MJ
DU, XP
LOFTUS, JC
GINSBERG, MH
机构
[1] Department of Vascular Biology, Scripps Research Institute, San Diego, CA 92037
来源
SEMINARS IN CELL BIOLOGY | 1995年 / 6卷 / 05期
关键词
PLATELETS; RECEPTORS; INTEGRINS; ALPHA-IIB-BETA-3; GPIB-IX;
D O I
10.1006/scel.1995.0040
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The response to vascular injury involves attachment and aggregation of platelets, coupled with initiation of the coagulation cascade. These inter-related processes ensure that the vessel injury is rapidly blocked with an aggregated clump of platelets that is then stabilized by a crosslinked fibrin matrix. Initial adherence relies on the ability of the platelet adhesion receptors to bind subendothelial matrix molecules. Platelet activation then results in the expression of high affinity integrin receptors on the cell surface that bind soluble ligands, allowing platelets to aggregate and form a haemostatic plug.
引用
收藏
页码:305 / 314
页数:10
相关论文
共 74 条
[1]   14-3-3 PROTEINS ON THE MAP [J].
AITKEN, A .
TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (03) :95-97
[2]  
ANDREWS RK, 1992, J BIOL CHEM, V267, P18605
[3]   ISOLATION OF THE THROMBOSPONDIN MEMBRANE-RECEPTOR [J].
ASCH, AS ;
BARNWELL, J ;
SILVERSTEIN, RL ;
NACHMAN, RL .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (04) :1054-1061
[4]   ANALYSIS OF CD36 BINDING DOMAINS - LIGAND SPECIFICITY CONTROLLED BY DEPHOSPHORYLATION OF AN ECTODOMAIN [J].
ASCH, AS ;
LIU, I ;
BRICCETTI, FM ;
BARNWELL, JW ;
KWAKYEBERKO, F ;
DOKUN, A ;
GOLDBERGER, J ;
PERNAMBUCO, M .
SCIENCE, 1993, 262 (5138) :1436-1440
[5]  
BAJT ML, 1994, J BIOL CHEM, V269, P20913
[6]  
Brass LF, 1991, HEMATOLOGY BASIC PRI, P1176
[7]   ASSIGNMENT OF DISULFIDE BONDS IN HUMAN PLATELET GPIIIA - A DISULFIDE PATTERN FOR THE BETA-SUBUNITS OF THE INTEGRIN FAMILY [J].
CALVETE, JJ ;
HENSCHEN, A ;
GONZALEZRODRIGUEZ, J .
BIOCHEMICAL JOURNAL, 1991, 274 :63-71
[8]  
CALVETE JJ, 1989, J BIOL CHEM, V260, P11366
[9]   SER-752-]PRO MUTATION IN THE CYTOPLASMIC DOMAIN OF INTEGRIN-BETA-3 SUBUNIT AND DEFECTIVE ACTIVATION OF PLATELET INTEGRIN-ALPHA-IIB-BETA-3 (GLYCOPROTEIN-IIB-IIIA) IN A VARIANT OF GLANZMANN THROMBASTHENIA [J].
CHEN, YP ;
DJAFFAR, I ;
PIDARD, D ;
STEINER, B ;
CIEUTAT, AM ;
CAEN, JP ;
ROSA, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10169-10173
[10]  
CHOW TW, 1992, BLOOD, V80, P113