SELECTIVE-INHIBITION OF THE TYROSINE KINASE PP60(SRC) BY ANALOGS OF 5,10-DIHYDROPYRIMIDO[4,5-B]QUINOLIN-4(1H)-ONE

被引：32

作者：

DOW, RL ^{[1
]}

BECHLE, BM ^{[1
]}

CHOU, TT ^{[1
]}

GODDARD, C ^{[1
]}

LARSON, ER ^{[1
]}

机构：

[1] ONCOGENE SCI,UNIONDALE,NY 11533

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 09期

关键词：

D O I：

10.1016/0960-894X(95)00157-O

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7,8-Dimethoxy-5,10-dihydropyrimido[4,5-b]quinolin-4(1H)-one (1b) has been discovered to be a potent and selective inhibitor of the tyrosine-specific kinase activity associated with pp60c-src. Mode of inhibition studies reveal that this agent inhibits in a pure-mixed-noncompetitive mode with respect to nucleotide co-factor.

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页码：1007 / 1010

页数：4

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