PAIN, WHEAL AND FLARE IN HUMAN FOREARM SKIN INDUCED BY BRADYKININ AND 5-HYDROXYTRYPTAMINE

被引：33

作者：

JENSEN, K

TUXEN, C

PEDERSENBJERGAARD, U

JANSEN, I

EDVINSSON, L

OLESEN, J

机构：

[1] MALMO GEN HOSP,DEPT EXPTL RES,S-21401 MALMO,SWEDEN

[2] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN

来源：

PEPTIDES | 1990年 / 11卷 / 06期

关键词：

AXON REFLEX; BRADYKININ; FLARE; 5-HYDROXYTRYPTAMINE; HUMAN; NOCICEPTION; PAIN; SKIN; WHEAL;

D O I：

10.1016/0196-9781(90)90142-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pain was induced in 19 healthy individuals by double-blind injections into the forearm skin of 0.05 ml of physiological saline with or without active substances added. Bradykinin (0.05 nmol), 5-hydroxytryptamine (0.05 nmol) and a mixture of the two substances in half dosage (0.25 nmol + 0.25 nmol) caused significantly more pain than saline ( p < 0.05). The three test solutions also induced wheal and flare responses significantly more pronounced than saline. Bradykinin induced significantly more pain and more wheal than 5-hydroxytryptamine (p < 0.05) but a significantly smaller flare (p < 0.01). A dissociation between induced pain and flare was thus demonstrated.

引用

页码：1133 / 1138

页数：6

共 29 条

[1] LATENCIES OF CHEMICALLY EVOKED DISCHARGES IN HUMAN CUTANEOUS NOCICEPTORS AND OF THE CONCURRENT SUBJECTIVE SENSATIONS [J].