CREATION OF AN ANTIGENIC SITE IN POLIOVIRUS TYPE-1 BY ASSEMBLY OF 14-S SUBUNITS

被引：27

作者：

ROMBAUT, B

BOEYE, A

FERGUSON, M

MINOR, PD

MOSSER, A

RUECKERT, R

机构：

[1] VRIJE UNIV BRUSSELS,DEPT MICROBIOL & HYG,LAARBEEKLAAN 103,B-1090 BRUSSELS,BELGIUM

[2] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

[3] UNIV WISCONSIN,INST MOLEC VIROL,MADISON,WI 53706

[4] NATL INST BIOL STAND & CONTROLS,POTTERS BAR EN6 3QG,HERTS,ENGLAND

来源：

VIROLOGY | 1990年 / 174卷 / 01期

关键词：

D O I：

10.1016/0042-6822(90)90080-B

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a set of neutralizing monoclonal antibodies targeted against the four known antigenic sites of poliovirus type 1, it was shown that three out of four antigenic sites are already present on 14 S subunits (pentamers of the structural unit). Site 3B, in contrast, is formed upon assembly of 14 S subunits into capsids. The data support the hypothesis that site 313 spans the boundary between pentamers in the virion. © 1990.

引用

页码：305 / 307

页数：3

共 11 条

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