DETERMINATION OF SEX CHROMOSOMAL CONSTITUTION AND CHROMOSOMAL ORIGIN OF DRUMSTICKS, DRUMSTICK-LIKE STRUCTURES, AND OTHER NUCLEAR-BODIES IN HUMAN BLOOD-CELLS AT INTERPHASE BY FLUORESCENCE INSITU HYBRIDIZATION

被引：9

作者：

MUKHERJEE, AB

PARSA, NZ

机构：

[1] Department of Biological Sciences, Fordham University, Bronx, 10458, NY

来源：

CHROMOSOMA | 1990年 / 99卷 / 06期

关键词：

D O I：

10.1007/BF01726695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sex chromosomal constitution has been determined in various types of human leukocytes at interphase by use of fluorescence in situ hybridization with X- and/or Y-specific DNA probes. It is found that during aging and differentiation of myelocytes into polymorphs there is no significant change in the relative frequency of various types of male and female cells with a specific type of sex chromosomal constitution. Nonrandom variability of the relative proximity between the X chromosomes within the nuclei is also observed in female cells. Moreover, we are the first to determine that sex-specific "drumsticks" and "sessile nodules" in female polymorphs originate from the X chromosomes and that non-sex-specific "drumstick-like" bodies in male polymorphs are of Y chromosomal origin. © 1990 Springer-Verlag.

引用

页码：432 / 435

页数：4

共 21 条

[1] A MORPHOLOGICAL DISTINCTION BETWEEN NEURONES OF THE MALE AND FEMALE, AND THE BEHAVIOUR OF THE NUCLEOLAR SATELLITE DURING ACCELERATED NUCLEOPROTEIN SYNTHESIS [J].