INDUCIBILITY OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS BY INTERFERON-GAMMA IS ASSOCIATED WITH REDUCED TUMORIGENICITY IN C3H MOUSE FIBROBLASTS TRANSFORMED BY V-KI-RAS

被引:21
作者
BATEMAN, WJ [1 ]
FIERA, R [1 ]
MATTHEWS, N [1 ]
MORRIS, AG [1 ]
机构
[1] UNIV COLL CARDIFF,COLL MED,DEPT MED MICROBIOL,CARDIFF CF4 4X4,WALES
关键词
D O I
10.1084/jem.173.1.193
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Paired lines of C3H mouse fibroblasts transformed with murine sarcoma virus (Kirsten strain) were prepared that express high or low levels of class II major histocompatibility complex antigen after treatment with interferon-gamma (IFN-gamma). Here, we described a comparison of the tumorigenicity of these lines in euthymic syngeneic and thymus-deficient mu/mu mice and in mice depleted of IFN-gamma. The class II-inducible cells are clearly less tumorigenic than the noninducible cells in syngeneic mice, but of similar tumorigenicity in mu/mu mice and in mice treated with antibodies to deplete IFN-gamma. We propose that in this system, IFN-gamma induction of class II antigens on the tumor cell surface operates to limit tumor growth; ras expression, which inhibits induction of class II antigens, prevents this and so allows tumor growth.
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页码:193 / 196
页数:4
相关论文
共 22 条
[1]  
BATEMAN WJ, 1987, IMMUNOLOGY, V61, P317
[3]   TUMORIGENICITY OF CELLS TRANSFORMED BY ADENOVIRUS-TYPE-12 BY EVASION OF T-CELL IMMUNITY [J].
BERNARDS, R ;
SCHRIER, PI ;
HOUWELING, A ;
BOS, JL ;
VANDEREB, AJ ;
ZIJLSTRA, M ;
MELIEF, CJM .
NATURE, 1983, 305 (5937) :776-779
[4]   PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS [J].
BOS, JL ;
FEARON, ER ;
HAMILTON, SR ;
VERLAANDEVRIES, M ;
VANBOOM, JH ;
VANDEREB, AJ ;
VOGELSTEIN, B .
NATURE, 1987, 327 (6120) :293-297
[5]   HISTOCOMPATIBILITY ANTIGENS ON MURINE TUMORS [J].
GOODENOW, RS ;
VOGEL, JM ;
LINSK, RL .
SCIENCE, 1985, 230 (4727) :777-783
[6]   THE INFLUENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGENS ON TUMOR-GROWTH AND METASTASIS [J].
HAMMERLING, GJ ;
KLAR, D ;
PULM, W ;
MOMBURG, F ;
MOLDENHAUER, G .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 907 (03) :245-259
[7]  
INFANTE AJ, 1988, J IMMUNOL, V140, P2462
[8]   MUTATIONS OF THE KIRSTEN-RAS PROTOONCOGENE IN HUMAN PRELEUKEMIA [J].
LIU, E ;
HJELLE, B ;
MORGAN, R ;
HECHT, F ;
BISHOP, JM .
NATURE, 1987, 330 (6144) :186-188
[9]   CONSTRUCTION OF A RETROVIRUS PACKAGING MUTANT AND ITS USE TO PRODUCE HELPER-FREE DEFECTIVE RETROVIRUS [J].
MANN, R ;
MULLIGAN, RC ;
BALTIMORE, D .
CELL, 1983, 33 (01) :153-159
[10]   KIRSTEN MURINE SARCOMA-VIRUS ABOLISHES INTERFERON GAMMA-INDUCED CLASS-II BUT NOT CLASS-I MAJOR HISTOCOMPATIBILITY ANTIGEN EXPRESSION IN A MURINE FIBROBLAST LINE [J].
MAUDSLEY, DJ ;
MORRIS, AG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (02) :706-711