KERAMAMIDE-A, A NOVEL PEPTIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA SP

被引：62

作者：

KOBAYASHI, J

SATO, M

ISHIBASHI, M

SHIGEMORI, H

NAKAMURA, T

OHIZUMI, Y

机构：

[1] SANKYO CO LTD,ANALYT & METAB RES LAB,SHINAGAWA KU,TOKYO 140,JAPAN

[2] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 10期

关键词：

D O I：

10.1039/p19910002609

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel peptide, keramamide A 1, has been isolated from the Okinawan marine sponge Theonella sp. and the structure established as a unique hexapeptide containing a hitherto unknown amino acid 6-chloro-5-hydroxy-N-methyltryptophan, and possessing an unusual ureido bond. The structural assignment was made on the basis of spectroscopic results (two-dimensional NMR: H-1-H-1 COSY, NOESY, ROESY, COLOC, HMQC, HMBC and HOHAHA; and FAB MS/MS).

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页码：2609 / 2611

页数：3

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