LIQUID-CHROMATOGRAPHY OF TIN-REDUCED TECHNETIUM HYDROXYETHYLIDENE DIPHOSPHONATE COMPLEXES FOR ONLINE SPECTRAL CHARACTERIZATION AND DOUBLE ISOTOPE LABELING

被引：18

作者：

MIKELSONS, MV ^{[1
]}

PINKERTON, TC ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

ANALYTICAL CHEMISTRY | 1986年 / 58卷 / 06期

关键词：

CHROMATOGRAPHIC ANALYSIS - Liquid - TRANSURANIUM ELEMENTS - Chromatographic Analysis;

D O I：

10.1021/ac00297a006

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An anion-exchange high-performance liquid chromatographic separation has been developed for tin-reduced technetium hydroxyethylidene diphosphonate complexes, Tc-HEDP, at millimolar concentrations of technetium-99. The separation facilitates the acquisition of ultraviolet-visible spectra of the Tc-HEDP complexes on-line with a diode array spectrophotometer. A precolumn backflush technique has been devised to remove unreacted pretechnetate from the chromatographic system after each injection, thus preventing on-column reactions from suqsequent samples containing Sn(II). The Tc-HEDP complexes were prepared at pH 2. 5, 7. 3, and 10. 0 to demonstrate the effect of pH on the distribution of complexes within the separation.

引用

页码：1007 / 1013

页数：7

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