CLONING OF A GROWTH ARREST-SPECIFIC AND TRANSFORMING GROWTH-FACTOR BETA-REGULATED GENE, TI-1, FROM AN EPITHELIAL-CELL LINE

被引：47

作者：

KALLIN, B ^{[1
]}

DEMARTIN, R ^{[1
]}

ETZOLD, T ^{[1
]}

SORRENTINO, V ^{[1
]}

PHILIPSON, L ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB, POSTFACH 10-2209, W-6900 HEIDELBERG, GERMANY

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 10期

关键词：

D O I：

10.1128/MCB.11.10.5338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By cDNA cloning and differential screening, five genes that are regulated by transforming growth factor-beta (TGF-beta) in mink lung epithelial cells were identified. A novel membrane protein gene, TI 1, was identified which was downregulated by TGF-beta and serum in quiescent cells. In actively growing cells, the TI 1 gene is rapidly and transiently induced by TGF-beta, and it is overexpressed in the presence of protein synthesis inhibitors. It appears to be related to a family of transmembrane glycoproteins that are expressed on lymphocytes and tumor cells. The four other genes were all induced by TGF-beta and correspond to the genes of collagen alpha type I, fibronectin, plasminogen activator inhibitor 1, and the monocyte chemotactic cell-activating factor (JE gene) previously shown to be TGF-beta regulated.

引用

页码：5338 / 5345

页数：8

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