BEHAVIORAL PROFILE OF THE 5HT1A RECEPTOR ANTAGONIST (S)-UH-301 IN RODENTS AND MONKEYS

被引：56

作者：

MOREAU, JL ^{[1
]}

GRIEBEL, G ^{[1
]}

JENCK, F ^{[1
]}

MARTIN, JR ^{[1
]}

WIDMER, U ^{[1
]}

HAEFELY, WE ^{[1
]}

机构：

[1] LAB PSYCHOPHYSIOL,F-67000 STRASBOURG,FRANCE

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 06期

关键词：

(S)-UH-301; 5HT1A ANTAGONIST; ANXIETY; MONKEY;

D O I：

10.1016/0361-9230(92)90163-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the new 5HT1A receptor antagonist (S)-UH-301 were investigated in several neurological and behavioral tests in rodents and monkeys. By itself, (S)-UH-301 was found to decrease palatable food consumption in rats, to exhibit anticonvulsant activity in mice, and anxiolytic-like properties in two rodent models of anxiety (light-dark test and elevated plus-maze test). (S)-UH-301 antagonized various symptoms and behaviors induced by the selective 5HT1A receptor agonist 8-OH-DPAT, such as lower lip retraction and flat body posture in rats, hyperphagia for palatable food in rats, and displacement activities (considered as indices of anxiety) in squirrel monkeys. These results further characterize (S)-UH-301 as an in vivo active 5HT1A receptor antagonist and suggest that this antagonistic activity might confer the compound with anxiolytic-like properties.

引用

页码：901 / 904

页数：4

共 18 条

[1] SELECTIVE ACTIVATION OF 5HT1A RECEPTORS INDUCES LOWER LIP RETRACTION IN THE RAT [J].