AMINOACYLATION OF TRANSFER-RNAS WITH 2-THIOURIDINE DERIVATIVES IN THE WOBBLE POSITION OF THE ANTICODON

被引：20

作者：

ROGERS, KC ^{[1
]}

CRESCENZO, AT ^{[1
]}

SOLL, D ^{[1
]}

机构：

[1] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06520

来源：

BIOCHIMIE | 1995年 / 77卷 / 1-2期

关键词：

AMINOACYLATION; TRANSFER-RNA; AMINOACYL-TRANSFER-RNA SYNTHETASE; MODIFIED NUCLEOSIDES; ANTISUPPRESSORS;

D O I：

10.1016/0300-9084(96)88106-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first position or 'wobble base' in the anticodon of tRNAs is frequently the site of post-transcriptional modification. In Escherichia coli, glutamine, glutamate, and lysine tRNAs contain 2-thiouridine derivatives in this position, and the significance of these modifications has been under investigation since their discovery. Here we describe the investigations to link 2-thiouridine derivatives to aminoacylation of these tRNAs. The implications of these findings on the evolution of specificity of aminoacyl-tRNA synthetases and on translational regulation are also discussed.

引用

页码：66 / 74

页数：9

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