EFFECTS OF KETOPROFEN AND PHENYLBUTAZONE ON CHRONIC HOOF PAIN AND LAMENESS IN THE HORSE

被引：55

作者：

OWENS, JG ^{[1
]}

KAMERLING, SG ^{[1
]}

STANTON, SR ^{[1
]}

KEOWEN, ML ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,SCH VET MED,DEPT VET PHYSIOL PHARMACOL & TOXICOL,BATON ROUGE,LA 70803

来源：

EQUINE VETERINARY JOURNAL | 1995年 / 27卷 / 04期

关键词：

HORSE; KETOPROFEN; PHENYLBUTAZONE; CHRONIC LAMINITIS; ANALGESIA; LAMENESS;

D O I：

10.1111/j.2042-3306.1995.tb03080.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The analgesic effects of the nonsteroidal anti-inflammatory drugs, ketoprofen (2.2 and 3.63 mg/kg bwt) and phenylbutazone (4.4 mg/kg bwt) were compared in 7 horses with chronic laminitis. Hoof pain was quantified objectively by means of an electronic hoof tester and lameness was subjectively graded on a modified Obel scale. Ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) reduced hoof pain and lameness to a greater extent than the 22 mg/kg dose and phenylbutazone. These effects were still present at 24 h in 3 of the 4 pain tests, including lameness grade. These data suggest that ketoprofen at the dosage rate of 1.65 times the recommended therapeutic dose was more potent than phenylbutazone in alleviating chronic pain and lameness in horses.

引用

页码：296 / 300

页数：5

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