METHOTREXATE ANALOGS .15. A METHOTREXATE ANALOG DESIGNED FOR ACTIVE-SITE-DIRECTED IRREVERSIBLE INACTIVATION OF DIHYDROFOLATE-REDUCTASE

被引：34

作者：

ROSOWSKY, A ^{[1
]}

WRIGHT, JE ^{[1
]}

GINTY, C ^{[1
]}

UREN, J ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1982年 / 25卷 / 08期

关键词：

D O I：

10.1021/jm00350a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：960 / 964

页数：5

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共 30 条

[1] BEIDLER JL, 1978, EUR J CANCER, V14, P41
[2] METHOTREXATE ANALOGS .3. SYNTHESIS AND BIOLOGICAL PROPERTIES OF SOME SIDE-CHAIN ALTERED ANALOGS
CHAYKOVSKY, M
ROSOWSKY, A
PAPATHANASOPOULOS, N
CHEN, KKN
MODEST, EJ
KISLIUK, RL
GAUMONT, Y
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (11) : 1212 - 1216
[3] METHOTREXATE ANALOGS .6. REPLACEMENT OF GLUTAMIC-ACID BY VARIOUS AMINO-ACID ESTERS AND AMINES
CHAYKOVSKY, M
BROWN, BL
MODEST, EJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (09) : 909 - 912
[4] COHEN M, 1978, CANCER RES, V38, P2866
[5] COLORIMETRIC ESTIMATION OF NITROGEN MUSTARDS IN AQUEOUS MEDIA - HYDROLYTIC BEHAVIOR OF BIS(BETA-CHLOROETHYL)AMINE, NOR HN2
FRIEDMAN, OM
BOGER, E
[J]. ANALYTICAL CHEMISTRY, 1961, 33 (07) : 906 - &
[6] A METHOTREXATE INSENSITIVE VARIANT OF FOLATE REDUCTASE PRESENT IN 2 LINE OF METHOTREXATE-RESISTANT L5178Y CELLS
GOLDIE, JH
KRYSTAL, G
HARTLEY, D
GUDAUSKAS, G
DEDHAR, S
[J]. EUROPEAN JOURNAL OF CANCER, 1980, 16 (12) : 1539 - 1546
[7] GOLDMAN ID, 1976, CANCER RES, V36, P276
[8] GOLDMAN ID, 1975, CANCER CHEMOTH REP 3, V6, P51
[9] GOLDMAN ID, 1974, MOL PHARMACOL, V10, P275
[10] DIHYDROFOLATE REDUCTASE FROM AMETHOPTERIN-RESISTANT LACTOBACILLUS-CASEI
GUNDERSEN, LE
HARDING, NGL
FREISHEIM, JH
OTTING, F
HUENNEKENS, FM
DUNLAP, RB
[J]. BIOCHEMISTRY, 1972, 11 (06) : 1018 - +