NUCLEOTIDE-SEQUENCE OF A UGANDAN HIV-1 PROVIRUS REVEALS GENETIC DIVERSITY FROM OTHER HIV-1 ISOLATES

被引：36

作者：

ORAM, JD

DOWNING, RG

ROFF, M

CLEGG, JCS

SERWADDA, D

CARSWELL, JW

机构：

[1] WHO,AIDS CONTROL PROGRAMME,ENTEBBE,UGANDA

[2] MULAGO HOSP,DEPT MED & PAEDIAT,KAMPALA,UGANDA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 09期

关键词：

D O I：

10.1089/aid.1990.6.1073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A Ugandan isolate of human immunodeficiency virus type 1 (HIV-1), designated U455, was adapted to growth in U937 cells, the provirus cloned into the lambda L47.1 vector, and its DNA sequence determined. The sequences of some of the U455 genes showed a marked divergence from those of North American and other African isolates. The sequenced clone was defective with single in-phase stop codons in the vpr and env genes and a frame shift, resulting in a stop codon, within the vpu gene. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：1073 / 1078

页数：6

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