EXPRESSION OF MULTIDRUG-RESISTANCE (MDR1) GENE IN NORMAL EPITHELIA AND IN INVASIVE CARCINOMAS OF THE UTERINE CERVIX

被引：20

作者：

RIOU, GF

ZHOU, D

AHOMADEGBE, JC

GABILLOT, M

DUVILLARD, P

LHOMME, C

机构：

[1] INST GUSTAVE ROUSSY,SERV GYNECOL,F-94800 VILLEJUIF,FRANCE

[2] INST GUSTAVE ROUSSY,ANATOMOPATHOL LAB,F-94800 VILLEJUIF,FRANCE

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1990年 / 82卷 / 18期

关键词：

D O I：

10.1093/jnci/82.18.1493

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Total RNA from 92 invasive cervical cancers was analyzed for the presence of multidrug-resistance (MDR1) gene (also known as PGY1) transcripts. A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low [mean, 2.5 arbitrary units (U)] except in one liver metastasis (50 U) treated with a drug regimen including vincristine. Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P =.01). In conclusion, our data suggest that the MDR1 gene plays a role in drug resistance of certain cervical cancers, but also that other mechanisms may be involved. [J Natl Cancer Inst 82: 1493-1496, 1990] © 1990 Oxford University Press.

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页码：1493 / 1496

页数：4

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