DESIGN OF A POLYVINYL-ALCOHOL HYDROGEL CONTAINING PHOSPHOLIPID AS CONTROLLED-RELEASE VEHICLE FOR RECTAL ADMINISTRATION OF (+/-)-PROPRANOLOL HCL

被引：12

作者：

MORIMOTO, K ^{[1
]}

FUKANOKI, S ^{[1
]}

HATAKEYAMA, Y ^{[1
]}

NAGAYASU, A ^{[1
]}

MORISAKA, K ^{[1
]}

HYON, SH ^{[1
]}

IKADA, Y ^{[1
]}

机构：

[1] KYOTO UNIV,MED POLYMER & BIOMAT RES CTR,SAKYO KU,KYOTO 606,JAPAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 10期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb06567.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— Polyvinyl alcohol hydrogels which contained phospholipid, egg yolk lecithin or hydrogenated soya lecithin were designed as a transrectal delivery system for propranolol hydrochloride. The hydrogel preparations containing phospholipid were prepared by a low‐temperature crystallization method. The release profile of propranolol from hydrogel preparations containing phospholipid complied with Fickian diffusion (Higuchi model). The release of propranolol from the hydrogel preparation decreased with higher contents of phospholipid (∼ 2% w/w). In rats plasma concentrations of propranolol after rectal administration of hydrogel preparations containing phospholipid (1 and 2% w/w) were prolonged compared with those of rats receiving preparations without phospholipid. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：720 / 722

页数：3

共 8 条

[1] THERMODYNAMICS OF PARTITIONING OF BETA-BLOCKERS IN THE NORMAL-OCTANOL-BUFFER AND LIPOSOME SYSTEMS [J].

BETAGERI, GV ;

ROGERS, JA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 36 (2-3) :165-173

[2]

DEBOER AG, 1982, PHARM INT, V1, P267

[3] COMBINED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PROCEDURE FOR MEASURING 4-HYDROXYPROPRANOLOL AND PROPRANOLOL IN PLASMA - PHARMACOKINETIC MEASUREMENTS FOLLOWING CONVENTIONAL AND SLOW-RELEASE PROPRANOLOL ADMINISTRATION [J].

DRUMMER, OH ;

MCNEIL, J ;

PRITCHARD, E ;

LOUIS, WJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (09) :1030-1032

[4]

MORIMOTO K, 1989, CHEM PHARM BULL, V37, P2491

[5] EVALUATION OF POLYVINYL-ALCOHOL HYDROGEL AS A SUSTAINED-RELEASE VEHICLE FOR RECTAL ADMINISTRATION OF INDOMETHACIN [J].

MORIMOTO, K ;

NAGAYASU, A ;

FUKANOKI, S ;

MORISAKA, K ;

HYON, SH ;

IKADA, Y .

PHARMACEUTICAL RESEARCH, 1989, 6 (04) :338-341

[6]

PEPPAS NA, 1985, PHARM ACTA HELV, V60, P110

[7] CLINICAL PHARMACOKINETICS OF BETA-ADRENOCEPTOR ANTAGONISTS - AN UPDATE [J].

RIDDELL, JG ;

HARRON, DWG ;

SHANKS, RG .

CLINICAL PHARMACOKINETICS, 1987, 12 (05) :305-320

[8] A PHARMACOKINETIC ANALYSIS PROGRAM (MULTI) FOR MICROCOMPUTER [J].

YAMAOKA, K ;

TANIGAWARA, Y ;

NAKAGAWA, T ;

UNO, T .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1981, 4 (11) :879-885

← 1 →