CHARACTERIZATION OF THE PROMOTER OF HUMAN PROSTAGLANDIN-H SYNTHASE-1 GENE

被引：99

作者：

WANG, LH ^{[1
]}

HAJIBEIGI, A ^{[1
]}

XU, XM ^{[1
]}

LOOSEMITCHELL, D ^{[1
]}

WU, KK ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,HOUSTON,TX 77030

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene of human prostaglandin H synthase-1 (PGHS-l, EC 1.14.99.1) was isolated from a human cosmid library and was contained in two overlapping clones. Multiple transcriptional start sites were identified. The major one located 136 bases upstream from the ATG initiation codon. The promoter region contains no canonical TATA box but possesses a high G+C content. These observations suggest that PGHS-1 gene has the characteristics of a housekeeping gene. Both 0.8 and 0.4 kb of the 5′-flanking sequence of the PGHS-1 gene can confer transcriptional activity. © 1993 Academic Press, Inc.

引用

页码：406 / 411

页数：6

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