1-NAPHTHYLMETHYLPHOSPHONIC ACID-DERIVATIVES AS OSTEOCLASTIC ACID-PHOSPHATASE INHIBITORS

被引：26

作者：

SCHWENDER, CF

BEERS, SA

MALLOY, E

DEMAREST, K

MINOR, L

LAU, KHW

机构：

[1] JERRY L PETTIS MEM VET ADM MED CTR,DEPT MINERAL METAB,LOMA LINDA,CA 92357

[2] RW JOHNSON PHARMACEUT RES INST,RARITAN,NJ 08869

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期

关键词：

D O I：

10.1016/0960-894X(95)00299-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inhibition of the enzyme, osteoclastic acid phosphatase (OAP) may be a viable approach to the treatment of osteoporosis. A series of arylmethylphosphonic acids were synthesized and shown to be inhibitors of OAP. The most potent inhibitor, bis-benzoyl-1-naphthylmethylphosphonic acid (7a) had an IC50 = 1.4 mu M.

引用

页码：1801 / 1806

页数：6

共 11 条

[1]

ARBUZOV BA, 1950, ZH OBSHCH KHIM+, V20, P1249

[2]

JOHNSON RA, Patent No. 9407501

[3] ISOMERIZATION OF ALKYL PHOSPHITES .4. THE SYNTHESIS OF SOME ALKARYL PHOSPHONIC ACIDS AND ESTERS [J].