STRUCTURE OF A HEXASACCHARIDE PROXIMAL TO THE HYDROPHOBIC REGION OF LIPOPOLYSACCHARIDES PRESENT IN BORDETELLA-PERTUSSIS ENDOTOXIN PREPARATIONS

被引：31

作者：

LEBBAR, S

CAROFF, M

SZABO, L

MERIENNE, C

SZILOGYI, L

机构：

[1] UNIV PARIS 11, CNRS, URA 1116, EQUIPE ENDOTOXINES, F-91405 ORSAY, FRANCE

[2] UNIV PARIS 11, INST CHIM MOLEC ORSAY, F-91405 ORSAY, FRANCE

[3] LAJOS KOSSUTH UNIV, INST ORGAN CHEM, H-4010 DEBRECEN, HUNGARY

来源：

CARBOHYDRATE RESEARCH | 1994年 / 259卷 / 02期

关键词：

D O I：

10.1016/0008-6215(94)84061-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A branched-chain hexasaccharide containing 3-deoxy-D-manno-oct-2-ulosonic acid was released by detergent-promoted hydrolysis from Bordetella pertussis endotoxin preparations that were first dephosphorylated with aqueous HF and then treated with nitrous acid. Its structure (2) [GRAPHICS] was determined by chemical and physical methods. This hexasaccharide is present in all four lipopolysaccharides that make up the B. pertussis strain 1414 (phase 1) endotoxin preparations analysed, and is situated near to the hydrophobic domains. An analogous structure reported previously (ref 7) is erroneous and should be disregarded.

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页码：257 / 275

页数：19

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