10-YEAR RESULTS COMPARING MASTECTOMY TO EXCISION AND RADIATION-THERAPY FOR DUCTAL CARCINOMA IN-SITU OF THE BREAST

被引：175

作者：

SILVERSTEIN, MJ

BARTH, A

POLLER, DN

GIERSON, ED

COLBURN, WJ

WAISMAN, JR

GAMAGAMI, P

机构：

[1] BREAST CTR,DIV PATHOL,VAN NUYS,CA 91405

[2] BREAST CTR,DIV MED ONCOL,VAN NUYS,CA 91405

[3] BREAST CTR,DIV BREAST IMAGING RADIOL,VAN NUYS,CA 91405

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 09期

关键词：

INTRADUCTAL BREAST CARCINOMA; DUCT CARCINOMA IN SITU; DCIS; NONINVASIVE BREAST CANCER; BREAST; NUCLEAR GRADE; LOCAL RECURRENCE; BREAST IRRADIATION;

D O I：

10.1016/0959-8049(95)00283-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 10-year results of 300 patients with ductal carcinoma in situ (DCIS) without microinvasion are reported; 167 treated with mastectomy and 133 treated with excision and radiation therapy. There was a significant difference in disease-free survival at 10 years, in favour of those treated with mastectomy, 98% versus 81% (P = 0.0004). Multivariate analysis confirmed nuclear grade as the only significant predictor of local recurrence (P = 0.02) or invasive local recurrence (P = 0.03) in patients with DCIS treated with excision and radiation therapy. There was no difference in breast cancer-specific survival or overall survival between the two treatment groups.

引用

页码：1425 / 1427

页数：3

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