CLONING AND CHROMOSOMAL LOCALIZATION OF A MOUSE CDNA WITH HOMOLOGY TO THE SACCHAROMYCES-CEREVISIAE GENE ZUOTIN

被引：9

作者：

HUGHES, R

CHAN, FY

WHITE, RA

ZON, LI

机构：

[1] CHILDRENS HOSP, DIV HEMATOL ONCOL, BOSTON, MA 02115 USA

[2] CHILDRENS HOSP, HOWARD HUGHES MED INST, BOSTON, MA 02115 USA

[3] HARVARD UNIV, CHILDRENS HOSP,SCH MED,DANA FARBER CANC INST, DEPT PEDIAT, BOSTON, MA 02115 USA

[4] UNIV MISSOURI, CHILDRENS MERCY HOSP, SCH MED, GENET SECT, KANSAS CITY, MO 64108 USA

来源：

GENOMICS | 1995年 / 29卷 / 02期

关键词：

D O I：

10.1006/geno.1995.9969

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The eukaryotic DnaJ homologs form a family of proteins with diverse functions. One member of the family, the Saccharomyces cerevisiae gene zuotin, was isolated for its ability to bind Z-DNA. Here, we have isolated a mouse cDNA called ZRF1 (for zuotin-related factor 1) with significant homology to zuotin. The DnaJ domain and candidate phosphorylation sites of zuotin and ZRF1 are highly conserved. ZRF1 is expressed in all tissues, and the mouse ZRF1 gene is localized on chromosome 5. The structural similarity of zuotin and ZRF1 suggests conservation of function of this DnaJ subfamily. (C) 1995 Academic Press, Inc.

引用

页码：546 / 550

页数：5

共 33 条

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