MULTIFOCAL LEUKOENCEPHALOPATHY - OCCURRENCE DURING 5-FLUOROURACIL AND LEVAMISOLE THERAPY AND RESOLUTION AFTER DISCONTINUATION OF CHEMOTHERAPY

被引：33

作者：

KIMMEL, DW ^{[1
]}

SCHUTT, AJ ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DIV MED ONCOL,ROCHESTER,MN 55905

来源：

MAYO CLINIC PROCEEDINGS | 1993年 / 68卷 / 04期

关键词：

D O I：

10.1016/S0025-6196(12)60132-3

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We report the fourth case of cerebral demyelinating disease associated with 5-fluorouracil and levamisole hydrochloride therapy for adenocarcinoma of the colon. The initial manifestations included subacute progressive decline in mental status, ataxia, dysarthria, and diplopia. Magnetic resonance imaging of the head demonstrated multifocal enhanced lesions in the white matter. The patient experienced improvement, without corticosteroid treatment, from 2 weeks to 4 months after cessation of chemotherapy.

引用

页码：363 / 365

页数：3

共 5 条

[1]

CAMPBELL TN, 1982, CANCER TREAT REP, V66, P1723

[2]

MULTIFOCAL INFLAMMATORY LEUKOENCEPHALOPATHY WITH 5-FLUOROURACIL AND LEVAMISOLE [J].