MODULATION OF THE CYTOKINE AND ACUTE-PHASE RESPONSE TO MAJOR SURGERY BY RECOMBINANT INTERLEUKIN-2

被引：16

作者：

DEEHAN, DJ ^{[1
]}

HEYS, SD ^{[1
]}

SIMPSON, W ^{[1
]}

BROOM, J ^{[1
]}

MCMILLAN, DN ^{[1
]}

EREMIN, O ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT CLIN BIOCHEM,ABERDEEN AB9 2ZD,SCOTLAND

来源：

BRITISH JOURNAL OF SURGERY | 1995年 / 82卷 / 01期

关键词：

D O I：

10.1002/bjs.1800820130

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Major surgery suppresses host immune reactivity through alterations in monocyte and T cell-derived cytokine, eicosanoid and acute-phase protein release. Recombinant interleukin (IL) 2 augments T lymphocyte and monocyte activity in vitro. Eighteen patients, with localized colorectal cancer, were randomized to receive either recombinant IL-2 or placebo for 3 days by subcutaneous injection before surgery. Serum levels of IL-1 beta, IL-6, tumour necrosis factor alpha, soluble IL-2 receptor, C-reactive protein (CRP) and albumin were measured, and T lymphocyte surface expression of HLA-DR and CD25 and neutrophil phagocytosis were determined, before and for 21 days after surgery. Significant augmentation of IL-6, CRP and soluble IL-2 receptor production, enhanced expression of activation markers and increased neutrophil activity were found. Recombinant IL-2 may have a role in ameliorating the immunosuppression found after major surgery.

引用

页码：86 / 90

页数：5

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