EPITOPE DISCOVERY USING PEPTIDE LIBRARIES DISPLAYED ON PHAGE

被引：125

作者：

CORTESE, R

FELICI, F

GALFRE, G

LUZZAGO, A

MONACI, P

NICOSIA, A

机构：

[1] Istituto di Ricerche di Biologia Molecolare P. Angeletti, 00040 Pomezia, Roma

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 07期

关键词：

D O I：

10.1016/0167-7799(94)90137-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.

引用

页码：262 / 267

页数：6

共 33 条

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