1,25-DIHYDROXYVITAMIN D-3 REGULATION OF MYOCARDIAL GROWTH AND C-MYC LEVELS IN THE RAT-HEART

被引：29

作者：

OCONNELL, TD ^{[1
]}

SIMPSON, RU ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT PHARMACOL,ANN ARBOR,MI 48109

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.2098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this report we demonstrate that rats maintained on a calcium supplemented vitamin D-3-deficient diet for nine weeks showed an increase in heart to body weight ratio. Morphometric analysis indicated that vitamin D-3 deficiency produced cardiac myocytes that were smaller yet more numerous, indicating hyperplasia, Western blot analysis showed that vitamin D-3 deficiency also resulted in increased c-myc protein levels in the hearts of vitamin D-3-deficient rats. Furthermore, 1,25-dihydroxyvitamin D-3 reduced c-myc protein levels in primary cultures of ventricular myocytes from neonatal rat hearts. Our data suggest a possible relationship between myocyte hyperplasia and increased c-myc levels in the vitamin D-3-deficient rat heart. (C) 1995 Academic Press, Inc.

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页码：59 / 65

页数：7

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