CLINICAL-SIGNIFICANCE OF SERUM S100 IN METASTATIC MALIGNANT-MELANOMA

被引:77
作者
GUO, HB
STOFFELWAGNER, B
BIERWIRTH, T
MEZGER, J
KLINGMULLER, D
机构
[1] UNIV BONN,DEPT CLIN BIOCHEM,D-53105 BONN,GERMANY
[2] UNIV BONN,DEPT DERMATOL,D-53105 BONN,GERMANY
[3] UNIV BONN,DEPT INTERNAL MED,D-53105 BONN,GERMANY
关键词
SERUM S100 PROTEIN; NEURON-SPECIFIC ENOLASE; MALIGNANT MELANOMA; TUMOR MARKER;
D O I
10.1016/0959-8049(95)00087-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
clinical significance of serum S100 was assessed in comparison to neuron-specific enolase (NSE) in 126 patients with malignant melanoma: 80 patients with clinical stage I/II, 23 patients with stage III and 23 patients with stage IV according to the criteria of the American Joint Committee on Cancer (AJCC). Using cut-off values of 0.15 mu g/l for S100 and 12.5 mu g/l for NSE, the sensitivity was found to be 1.3% (1/80) for S100 and 8.75% (7/80) for NSE in patients with stage I/II, 8.7% (2/23) for S100 and 13% (8/23) for NSE in patients with stage III, and 73.9% (17/23) for S100 and 34.8% (8/23) for NSE in patients with stage IV disease (P < 0.05). In 6 patients with stage III/IV tumours, serial measurement of serum S100 and NSE was performed, A rise of serum S100 indicated progression of the disease; a decline indicated response to treatment. Our preliminary results support the value of serum S100 as an adjunct to the clinical staging and monitoring of metastatic malignant melanoma.
引用
收藏
页码:924 / 928
页数:5
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