PHENCYCLIDINE IMPAIRS TEMPORAL-ORDER MEMORY FOR SPATIAL LOCATIONS IN RATS

被引：14

作者：

LONG, JM ^{[1
]}

KESNER, RP ^{[1
]}

机构：

[1] UNIV UTAH,DEPT PSYCHOL,SALT LAKE CITY,UT 84112

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 52卷 / 03期

关键词：

PHENCYCLIDINE; HIPPOCAMPUS; NMDA; RATS; LEARNING AND MEMORY;

D O I：

10.1016/0091-3057(95)00132-G

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of phencyclidine (PCP), an NMDA antagonist, was assessed on a complex task that has been shown to be dependent on hippocampal function. This task required memory for the temporal order of spatial locations. Rats were given IP injections of saline or PCP (3-4 mg/kg) on a double alternation schedule. With PCP injections rats were severely impaired relative to saline injections. Furthermore, PCP was shown to have no effects on the ability of rats to discriminate three-dimensional objects (a task that is not dependent on hippocampal function). The present data, in conjunction with previous results, suggest that the involvement of NMDA receptors in the hippocampus might be a function of the complexity of the task.

引用

页码：645 / 648

页数：4

共 16 条

[1] PHENCYCLIDINE SUPPRESSES HIPPOCAMPAL LONG-TERM POTENTIATION THROUGH STEREOSPECIFIC ACTIVATION OF PHENCYCLIDINE RECEPTORS [J].