AN EPSTEIN-BARR VIRUS-SPECIFIC CYTOTOXIC T-CELL EPITOPE IN EBV NUCLEAR ANTIGEN-3 (EBNA-3)

被引：157

作者：

BURROWS, SR ^{[1
]}

SCULLEY, TB ^{[1
]}

MISKO, IS ^{[1
]}

SCHMIDT, C ^{[1
]}

MOSS, DJ ^{[1
]}

机构：

[1] QUEENSLAND INST MED RES,BRAMSTON TERRACE,HERSTON,QLD 4006,AUSTRALIA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 171卷 / 01期

关键词：

D O I：

10.1084/jem.171.1.345

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV)-specific CTL clones were isolated that recognized A-type EBV transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8 restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2, 3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells (either autologous B-type transformants or PHA blasts). This report is the first description of an EBV target epitope recognized by specific CTL clones.

引用

页码：345 / 349

页数：5

共 14 条

[1] U2 REGION OF EPSTEIN-BARR VIRUS-DNA MAY ENCODE EPSTEIN-BARR NUCLEAR ANTIGEN-2 [J].

DAMBAUGH, T ;

HENNESSY, K ;

CHAMNANKIT, L ;

KIEFF, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23) :7632-7636

[2] T-CELL ANTIGENIC SITES TEND TO BE AMPHIPATHIC STRUCTURES [J].

DELISI, C ;

BERZOFSKY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7048-7052

[3] DOWN-REGULATION OF CELL-ADHESION MOLECULES LFA-3 AND ICAM-1 IN EPSTEIN-BARR VIRUS-POSITIVE BURKITTS-LYMPHOMA UNDERLIES TUMOR-CELL ESCAPE FROM VIRUS-SPECIFIC T-CELL SURVEILLANCE [J].

GREGORY, CD ;

MURRAY, RJ ;

EDWARDS, CF ;

RICKINSON, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (06) :1811-1824

[4] GENERAL-METHOD FOR THE RAPID SOLID-PHASE SYNTHESIS OF LARGE NUMBERS OF PEPTIDES - SPECIFICITY OF ANTIGEN-ANTIBODY INTERACTION AT THE LEVEL OF INDIVIDUAL AMINO-ACIDS [J].

HOUGHTEN, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) :5131-5135

[5] DOWN-REGULATION OF CLASS-I HLA ANTIGENS AND OF THE EPSTEIN-BARR VIRUS-ENCODED LATENT MEMBRANE-PROTEIN IN BURKITT-LYMPHOMA LINES [J].

MASUCCI, MG ;

TORSTEINDOTTIR, S ;

COLOMBANI, J ;

BRAUTBAR, C ;

KLEIN, E ;

KLEIN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (13) :4567-4571

[6] HLA-DR-ANTIGEN-ASSOCIATED RESTRICTION OF EBV-SPECIFIC CYTO-TOXIC T-CELL COLONIES [J].

MISKO, IS ;

POPE, JH ;

HUTTER, R ;

SOSZYNSKI, TD ;

KANE, RG .

INTERNATIONAL JOURNAL OF CANCER, 1984, 33 (02) :239-243

[7] CYTO-TOXIC T-CELL CLONES DISCRIMINATE BETWEEN A-TYPE AND B-TYPE EPSTEIN-BARR VIRUS TRANSFORMANTS [J].

MOSS, DJ ;

MISKO, IS ;

BURROWS, SR ;

BURMAN, K ;

MCCARTHY, R ;

SCULLEY, TB .

NATURE, 1988, 331 (6158) :719-721

[8]

RICKINSON AB, 1981, CANCER RES, V41, P4216

[9] A SEQUENCE PATTERN COMMON TO T-CELL EPITOPES [J].

ROTHBARD, JB ;

TAYLOR, WR .

EMBO JOURNAL, 1988, 7 (01) :93-100

[10] DISTINCTION BETWEEN EPSTEIN-BARR VIRUS TYPE-A (EBNA-2A) AND TYPE-B (EBNA-2B) ISOLATES EXTENDS TO THE EBNA-3 FAMILY OF NUCLEAR PROTEINS [J].

ROWE, M ;

YOUNG, LS ;

CADWALLADER, K ;

PETTI, L ;

KIEFF, E ;

RICKINSON, AB .

JOURNAL OF VIROLOGY, 1989, 63 (03) :1031-1039

← 1 2 →