IS HYPOXIA A STIMULUS FOR SYNTHESIS OF OXIDATIVE-ENZYMES AND MYOGLOBIN

被引:197
作者
TERRADOS, N
JANSSON, E
SYLVEN, C
KAIJSER, L
机构
[1] KAROLINSKA HOSP, DEPT CLIN PHYSIOL, S-10401 STOCKHOLM 60, SWEDEN
[2] HUDDINGE HOSP, DEPT INTERNAL MED, S-10401 STOCKHOLM, SWEDEN
[3] HUDDINGE HOSP, DEPT CLIN PHYSIOL, S-10401 STOCKHOLM, SWEDEN
关键词
citrate synthase; creatine kinase; high altitude; human; lactate dehydrogenase; physical training; skeletal muscle;
D O I
10.1152/jappl.1990.68.6.2369
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To compare two situations with similar magnitudes of mitochondrial substrate flux but different blood oxygen contents, one-legged training was employed. Ten healthy subjects trained one leg under normobaric conditions and the other under hypobaric conditions. At each session the subjects trained each leg for 30 min. The absolute work intensity was the same for both legs and was chosen to correspond to 65% of the average (right and left) pretraining one-legged maximal work capacity. There were three to four training sessions per week for 4 wk. Muscle biopsies from each leg were taken before and after training and analyzed for fiber types, capillaries, myoglobin, and oxidative and glycolytic enzymes. The most striking finding was a greater increase of citrate synthase activity under hypobaric conditions than under normobaric conditions. In addition, the myoglobin content increased in the leg trained under hypobaric conditions, whereas it tended to decrease in the normobarically trained leg. Because both legs were trained at the same intensity, the oxygen turnover and the substrate flux through the carboxylic acid cycle and the respiratory chain must have been of similar magnitude. Thus a difference in substrate flux is less likely to have caused the differences in enzyme activities and myoglobin content between training under normobaric and hypobaric conditions. Instead, the stimulus seems to be related to the blood oxygen content or tension.
引用
收藏
页码:2369 / 2372
页数:4
相关论文
共 33 条
[1]   CAPILLARY DENSITY IN SKELETAL-MUSCLE OF MAN [J].
ANDERSEN, P .
ACTA PHYSIOLOGICA SCANDINAVICA, 1975, 95 (02) :203-205
[2]  
[Anonymous], 1974, Scand J Clin Lab Invest, V33, P291, DOI 10.3109/00365517409082499
[3]  
BERGSTROM J, 1962, SCAND J CLIN LAB I S, V68
[4]   3 MYOSIN ADENOSINE TRIPHOSPHATASE SYSTEMS - NATURE OF THEIR PH LABILITY AND SULFHYDRYL DEPENDENCE [J].
BROOKE, MH ;
KAISER, KK .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1970, 18 (09) :670-&
[5]   ENERGY-METABOLISM IN CONTRACTING RAT SKELETAL-MUSCLE - ADAPTATION TO EXERCISE TRAINING [J].
CONSTABLE, SH ;
FAVIER, RJ ;
MCLANE, JA ;
FELL, RD ;
CHEN, M ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (02) :C316-C322
[6]  
DUDLEY GA, 1987, J BIOL CHEM, V262, P9109
[7]   HYPOXEMIA INCREASES PLASMA-CATECHOLAMINE CONCENTRATIONS IN EXERCISING HUMANS [J].
ESCOURROU, P ;
JOHNSON, DG ;
ROWELL, LB .
JOURNAL OF APPLIED PHYSIOLOGY, 1984, 57 (05) :1507-1511
[8]   METABOLIC CHARACTERISTICS OF FIBER TYPES IN HUMAN SKELETAL-MUSCLE [J].
ESSEN, B ;
JANSSON, E ;
HENRIKSSON, J ;
TAYLOR, AW ;
SALTIN, B .
ACTA PHYSIOLOGICA SCANDINAVICA, 1975, 95 (02) :153-165
[9]   ADAPTIVE RESPONSES OF RATS TO PROLONGED TREATMENT WITH EPINEPHRINE [J].
FELL, RD ;
TERBLANCHE, SE ;
WINDER, WW ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 241 (01) :C55-C58
[10]   MINIMUM INTRACELLULAR PO2 FOR MAXIMUM CYTOCHROME TURNOVER IN RED MUSCLE INSITU [J].
GAYESKI, TEJ ;
CONNETT, RJ ;
HONIG, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (05) :H906-H915