CORE PROTEIN OF CHONDROITIN SULFATE PROTEOGLYCAN PROMOTES NEURITE OUTGROWTH FROM CULTURED NEOCORTICAL NEURONS

被引：97

作者：

IIJIMA, N

OOHIRA, A

MORI, T

KITABATAKE, K

KOHSAKA, S

机构：

[1] NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN

[2] ASAHI BREWERY CO LTD,CENT RES LABS,DEPT BIOCHEM,TOKYO,JAPAN

[3] INST DEV RES,DEPT EMBRYOL,KASUGAI,AICHI 48003,JAPAN

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 56卷 / 02期

关键词：

CHONDROITIN SULFATE PROTEOGLYCAN; CORE PROTEIN; NEURITE OUTGROWTH; PRIMARY CULTURE;

D O I：

10.1111/j.1471-4159.1991.tb08207.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chondroitin sulfate proteoglycan (CS-PG) was purified from rat brain and examined for its effect on neurite outgrowth in primary cultures of embryonic rat neocortical neurons. Neurite outgrowth was increased in culture wells coated with CS-PG. The core protein and glycosaminoglycan (GAG) prepared from the CS-PG were also examined for neurite-promoting activity. The activity was observed in culture wells coated with the core protein but not with GAG. These results suggest that CS-PG stimulates neurite outgrowth from the cultured neurons via its core protein.

引用

页码：706 / 708

页数：3

共 18 条

[1] IMMUNOCYTOCHEMICAL LOCALIZATION OF A CHONDROITIN SULFATE PROTEOGLYCAN IN NERVOUS-TISSUE .2. STUDIES IN DEVELOPING BRAIN [J].