BIOTRANSFORMATIONS USING CLOSTRIDIA - STEREOSPECIFIC REDUCTIONS OF A BETA-KETO ESTER

被引：5

作者：

CHRISTEN, M

CROUT, DHG

HOLT, RA

MORRIS, JG

SIMON, H

机构：

[1] UNIV COLL WALES ABERYSTWYTH,DEPT BIOL SCI,ABERYSTWYTH SY23 3DA,DYFED,WALES

[2] TECH UNIV MUNICH,INST ORGAN CHEM,W-8046 GARCHING,GERMANY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 04期

关键词：

D O I：

10.1039/p19920000491

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reduction of methyl 4-(4-chlorophenylthio)-3-oxobutanoate 1 by clostridia has been studied. Clostridium pasteurianum ATCC 6013, C. tyrobutyricum DSM 1460 and C. kluyveri NCIB 10680 gave the D-(3S) reduction product 2, whereas C. kluyveri DSM 555 gave the L-(3R) reduction product 3. The products could be obtained in higher optical purities than by yeast reductions.

引用

页码：491 / 493

页数：3

共 12 条

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