STRUCTURE AND ORIENTATION OF THE SURFACTANT-ASSOCIATED PROTEIN-C IN A LIPID BILAYER

被引：161

作者：

VANDENBUSSCHE, G

CLERCX, A

CURSTEDT, T

JOHANSSON, J

JORNVALL, H

RUYSSCHAERT, JM

机构：

[1] UNIV LIBRE BRUXELLES,HOP ENFANTS REINE FABIOLA,DEPT NEONATOL,B-1050 BRUSSELS,BELGIUM

[2] KAROLINSKA INST,DANDERYD HOSP,DEPT CLIN CHEM,S-10401 STOCKHOLM 60,SWEDEN

[3] KAROLINSKA INST,DEPT CHEM 1,S-10401 STOCKHOLM 60,SWEDEN

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1992年 / 203卷 / 1-2期

关键词：

D O I：

10.1111/j.1432-1033.1992.tb19848.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The secondary structure of native and depalmitoylated porcine surfactant-associated protein C (SP-C) was studied by attenuated total reflection Fourier-transform infrared spectroscopy. Both forms of porcine SP-C adopt mainly an alpha-helical conformation. These two forms of the protein were reconstituted in a lipid bilayer. The insertion of the protein in a membrane is associated with an increase of the alpha-helical content. Dichroic measurements show that, in both cases, the long axis of the alpha-helix is oriented parallel to the lipid acyl chains.

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页码：201 / 209

页数：9

相关论文

共 53 条

[1] ALIGNMENT AND DEFECT STRUCTURES IN ORIENTED PHOSPHATIDYLCHOLINE MULTILAYERS [J].

ASHER, SA ;

PERSHAN, PS .

BIOPHYSICAL JOURNAL, 1979, 27 (03) :393-421

[2] ORIENTED SECONDARY STRUCTURE IN INTEGRAL MEMBRANE-PROTEINS .1. CIRCULAR-DICHROISM AND INFRARED-SPECTROSCOPY OF CYTOCHROME-OXIDASE IN MULTILAMELLAR FILMS [J].

BAZZI, MD ;

WOODY, RW .

BIOPHYSICAL JOURNAL, 1985, 48 (06) :957-966

[3] EXAMINATION OF THE SECONDARY STRUCTURE OF PROTEINS BY DECONVOLVED FTIR SPECTRA [J].

BYLER, DM ;

SUSI, H .

BIOPOLYMERS, 1986, 25 (03) :469-487

[4]

CABIAUX V, 1989, J BIOL CHEM, V264, P4928

[5]

CHIN JJ, 1986, J BIOL CHEM, V261, P7101

[6] SURFACE-INDUCED LAMELLAR ORIENTATION OF MULTILAYER MEMBRANE ARRAYS - THEORETICAL-ANALYSIS AND A NEW METHOD WITH APPLICATION TO PURPLE MEMBRANE-FRAGMENTS [J].

CLARK, NA ;

ROTHSCHILD, KJ ;

LUIPPOLD, DA ;

SIMON, BA .

BIOPHYSICAL JOURNAL, 1980, 31 (01) :65-96

[7] INTRINSIC PROTEIN-LIPID INTERACTIONS - INFRARED SPECTROSCOPIC STUDIES OF GRAMICIDIN-A, BACTERIORHODOPSIN AND CA-2+-ATPASE IN BIOMEMBRANES AND RECONSTITUTED SYSTEMS [J].

CORTIJO, M ;

ALONSO, A ;

GOMEZFERNANDEZ, JC ;

CHAPMAN, D .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 157 (04) :597-618

[8] LOW-MOLECULAR-MASS SURFACTANT PROTEIN TYPE-1 - THE PRIMARY STRUCTURE OF A HYDROPHOBIC 8-KDA POLYPEPTIDE WITH 8 HALF-CYSTINE RESIDUES [J].

CURSTEDT, T ;

JOHANSSON, J ;

BARROSSODERLING, J ;

ROBERTSON, B ;

NILSSON, G ;

WESTBERG, M ;

JORNVALL, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (03) :521-525

[9] 2 HYDROPHOBIC LOW-MOLECULAR-MASS PROTEIN-FRACTIONS OF PULMONARY SURFACTANT - CHARACTERIZATION AND BIOPHYSICAL ACTIVITY [J].

CURSTEDT, T ;

JORNVALL, H ;

ROBERTSON, B ;

BERGMAN, T ;

BERGGREN, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 168 (02) :255-262

[10] HYDROPHOBIC SURFACTANT-ASSOCIATED POLYPEPTIDES - SP-C IS A LIPOPEPTIDE WITH 2 PALMITOYLATED CYSTEINE RESIDUES, WHEREAS SP-B LACKS COVALENTLY LINKED FATTY ACYL-GROUPS [J].

CURSTEDT, T ;

JOHANSSON, J ;

PERSSON, P ;

EKLUND, A ;

ROBERTSON, B ;

LOWENADLER, B ;

JORNVALL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :2985-2989

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