WHOLE-CELL RECORDINGS OF SPONTANEOUS SYNAPTIC CURRENTS IN MEDIAL PREOPTIC NEURONS FROM RAT HYPOTHALAMIC SLICES - MEDIATION BY AMINO-ACID NEUROTRANSMITTERS

被引：20

作者：

HOFFMAN, NW ^{[1
]}

WUARIN, JP ^{[1
]}

DUDEK, FE ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,CTR HLTH SCI,MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1994年 / 660卷 / 02期

关键词：

MEDIAL PREOPTIC AREA; WHOLE-CELL PATCH-CLAMP RECORDING; GABA; GLUTAMATE;

D O I：

10.1016/0006-8993(94)91312-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Whole-cell recordings in hypothalamic slices from immature rats were used to test the hypothesis that inhibitory and excitatory amino acid neurotransmitters mediate fast synaptic currents in the medial preoptic area (MPOA). Bicuculline methiodide reversibly blocked spontaneous inhibitory postsynaptic currents (IPSCs), and 6-cyano-2,3-dihydroxy-7-nitroquinoxaline (CNQX) blocked spontaneous excitatory postsynaptic currents (EPSCs). These competitive antagonists act at gamma-aminobutyric acid (GABA), and non-N-methyl-D-aspartate (NMDA) glutamate receptors, respectively, thus supporting the hypothesis that these amino acid receptors activate most if not all fast synaptic currents in the MPOA.

引用

页码：349 / 352

页数：4

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