ACTIVATION AND INACTIVATION OF THE OSTEOCLAST CA-2+ RECEPTOR BY THE TRIVALENT CATION, LA-3+

被引:28
作者
SHANKAR, VS [1 ]
ALAM, ASMT [1 ]
BAX, CMR [1 ]
BAX, BE [1 ]
PAZIANAS, M [1 ]
HUANG, CLH [1 ]
ZAIDI, M [1 ]
机构
[1] UNIV CAMBRIDGE, PHYSIOL LAB, CAMBRIDGE CB2 3EG, ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1016/0006-291X(92)91283-V
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report changes in the cytosolic Ca2+ concentration ([Ca2+]i) of single rat osteoclasts in response to Ca2+ receptor activation by micromolar concentrations of the lanthanide metal cation, La3+. The extracellular application of La3+ induced a concentration-dependent elevation of cytosolic [Ca2+]. Prior conditioning of osteoclasts with La3+ resulted in a concentration-dependent reduction of the response to a subsequent application of a maximally effective concentration of Ni2+, a known agonist of the osteoclast Ca2+ receptor. The results establish that the osteoclast Ca2+ receptor is highly sensitive to activation and inactivation by the trivalent cation, La3+. © 1992.
引用
收藏
页码:907 / 912
页数:6
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