ACTIVATION AND INACTIVATION OF THE OSTEOCLAST CA-2+ RECEPTOR BY THE TRIVALENT CATION, LA-3+

被引：28

作者：

SHANKAR, VS ^{[1
]}

ALAM, ASMT ^{[1
]}

BAX, CMR ^{[1
]}

BAX, BE ^{[1
]}

PAZIANAS, M ^{[1
]}

HUANG, CLH ^{[1
]}

ZAIDI, M ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, PHYSIOL LAB, CAMBRIDGE CB2 3EG, ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(92)91283-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report changes in the cytosolic Ca2+ concentration ([Ca2+]i) of single rat osteoclasts in response to Ca2+ receptor activation by micromolar concentrations of the lanthanide metal cation, La3+. The extracellular application of La3+ induced a concentration-dependent elevation of cytosolic [Ca2+]. Prior conditioning of osteoclasts with La3+ resulted in a concentration-dependent reduction of the response to a subsequent application of a maximally effective concentration of Ni2+, a known agonist of the osteoclast Ca2+ receptor. The results establish that the osteoclast Ca2+ receptor is highly sensitive to activation and inactivation by the trivalent cation, La3+. © 1992.

引用

页码：907 / 912

页数：6

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