TH1 AND TH2 T-CELL SUBSETS ARE DIFFERENTIALLY ACTIVATED BY MACROPHAGES AND B-CELLS IN MURINE LEISHMANIASIS

被引：53

作者：

ROSSIBERGMANN, B ^{[1
]}

MULLER, I ^{[1
]}

GODINHO, EB ^{[1
]}

机构：

[1] UNIV LAUSANNE, WHO, INST BIOCHEM, CTR IMMUNOL RES & TRAINING, CH-1066 EPALINGES, SWITZERLAND

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 05期

关键词：

D O I：

10.1128/IAI.61.5.2266-2269.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of antigen-presenting cells in the differential expansion of TH1 and TH2 T cells in murine leishmaniasis was investigated. In general, macrophages preferentially induced gamma interferon and interleukin-2 secretion by syngeneic Leishmania-specific T cells, whereas B cells were more efficient in activating interleukin 4 production. B cells from susceptible BALB/c mice were better in inducing TH2 responses than B cells from resistant C57BL/6 mice, whereas macrophages from C57BL/6 mice were superior to BALB/c macrophages in inducing TH1 responses.

引用

页码：2266 / 2269

页数：4

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