CHANGES IN CIRCULATING PLASMA MET-ENKEPHALIN CONCENTRATIONS IN FELINE INTESTINAL ISCHEMIA - REPERFUSION

被引：5

作者：

ANEMAN, A

MEDBAK, S

WATSON, D

HAGLIND, E

机构：

[1] SAHLGRENS UNIV HOSP,DEPT SURG,S-41345 GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT PHYSIOL,GOTHENBURG,SWEDEN

[3] UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,DEPT INTENS CARE MED,LONDON,ENGLAND

[4] UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,DEPT CHEM ENDOCRINOL,LONDON,ENGLAND

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1994年 / 194卷 / 02期

关键词：

INTESTINAL ISCHEMIA; REPERFUSION; MET-ENKEPHALIN; MUCOSAL LESION; SHOCK;

D O I：

10.1007/BF02576373

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Plasma met-enkephalin-like immunoreactivity (MLI) levels were determined in cats before, during and after 90 min of intestinal ischemia followed by reperfusion and compared with the levels in control cats. Blood pressure and heart rate were registered and small intestinal mucosal lesions were graded. In control animals, the circulation was stable and there were no mucosal injuries. In the shock group, blood pressure decreased, heart rate increased and severe mucosal lesions were found. The circulating MLI levels were significantly higher 30 min after reperfusion of the ischemic intestine in the shock group than in the control group. There were correlations between MLI and tachycardia and hypotension respectively. Met-enkephalin was released in shock animals after reperfusion of the ischemic intestine and may explain naloxone responsiveness in intestinal shock models.

引用

页码：129 / 138

页数：10

共 32 条

[1]

CHIU CJ, 1970, ARCH SURG-CHICAGO, V101, P478

[2] DEVELOPMENT OF A SPECIFIC EXTRACTED RADIOIMMUNOASSAY FOR METHIONINE ENKEPHALIN IN HUMAN-PLASMA AND CEREBROSPINAL-FLUID [J].