CHARACTERIZATION OF 1,4-BENZOTHIAZINE INTERMEDIATES IN THE OXIDATIVE CONVERSION OF 5-S-CYSTEINYLDOPA TO PHEOMELANINS

被引：25

作者：

NAPOLITANO, A ^{[1
]}

COSTANTINI, C ^{[1
]}

CRESCENZI, O ^{[1
]}

PROTA, G ^{[1
]}

机构：

[1] UNIV NAPLES FEDERICO II,DEPT ORGAN & BIOL CHEM,I-80134 NAPLES,ITALY

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)73434-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under biologically relevant conditions, oxidation of 5-S-cysteinyldopa (1) to pheomelanins proceeds through the formation of the 1,4-benothiazine 7 along with the 3-carboxy analogue 6 in much smaller amounts, as evidenced by isolation of the reduced forms 5 and 4 and by deuterium labelling experiments.

引用

页码：6365 / 6368

页数：4

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