EFFECTS OF FLUOXETINE AND DESIPRAMINE ON PALATABILITY-INDUCED ETHANOL-CONSUMPTION IN THE ALCOHOL-NONPREFERRING (NP) LINE OF RATS

被引:19
作者
GATTO, GJ
MURPHY, JM
MCBRIDE, WJ
LUMENG, L
LI, TK
机构
[1] PURDUE UNIV,SCH SCI,DEPT PSYCHOL,KB 54,1125 E 38TH ST,INDIANAPOLIS,IN 46205
[2] INDIANA UNIV,SCH MED,INST PSYCHIAT RES,INDIANAPOLIS,IN 46202
[3] INDIANA UNIV,SCH MED,REGENSTRIEF INST,INDIANAPOLIS,IN 46202
[4] RICHARD L ROUDEBUSH VET ADM MED CTR,INDIANAPOLIS,IN 46202
关键词
Alcohol-nonpreferring NP rats; Desipramine; Fluoxetine; Food intake; Palatability-induced ethanol drinking;
D O I
10.1016/0741-8329(90)90044-D
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Three groups of NP rats (n = 5/group) received food, water and one of 3 Polycose solutions ad lib. One group received a solution containing 3% (w/v) Polycose, 0.125% (w/v) saccharin, 0.5% (w/v) NaCl (3% POL solution) to which ethanol was gradually added over three weeks until the concentration of 10% (v/v) ethanol (E) was reached (3% POL + E group). Alcohol ingestion by the 3% POL + E group reached an average of 9 g of ethanol/kg b.wt./day; the rats attained average blood alcohol concentrations of 61 ± 8 mg%. One control group (3% POL) was given the same solution as above but without ethanol. The second control group (17% POL) had access to a 17.6% Polycose solution supplemented with 0.125% saccharin and 0.5% NaCl and was isocaloric to the 3% POL + E solution. Although the three groups differed significantly in the amounts of food and Polycose solutions consumed, their total caloric intakes were equivalent. The IP administration of the serotonin (5-HT) uptake inhibitor fluoxetine (5 and 10 mg/kg) significantly reduced drinking of the group receiving the 3% POL + E solution by 23% and 67%, respectively, but did not alter intakes of the Polycose solutions by the 3% or 17% POL control groups. The IP administration of the norepinephrine (NE) uptake inhibitor desipramine (5 and 10 mg/kg) significantly reduced intake of the Polycose solution by the 17% POL group by 52 and 83%, respectively, but only the 10 mg/kg dose attenuated drinking of the solutions by the 3% POL and 3% POL + E groups. Both fluoxetine and desipramine decreased food intake of the 3% POL and 3% POL + E groups, while only desipramine suppressed food intake of the 17% POL rats. The data show that (a) NP rats can be induced to drink pharmacologically relevant amounts of ethanol when offered in a palatable solution, (b) fluoxetine preferentially reduces ethanol intake by NP rats through its actions on 5-HT systems that presumably mediate the aversive properties of ethanol, and (c) a carbohydrate-rich diet appears to alter the anorectic actions of NE and 5-HT uptake inhibitors in the NP rat. © 1990.
引用
收藏
页码:531 / 536
页数:6
相关论文
共 44 条
[1]  
AMIT Z, 1984, NEUROSCI BIOBEHAV RE, V8, P34
[2]  
BICE P J, 1989, Society for Neuroscience Abstracts, V15, P36
[3]   SEROTONIN AND APPETITE [J].
BLUNDELL, JE .
NEUROPHARMACOLOGY, 1984, 23 :1537-1551
[4]  
BLUNDELL JE, 1989, PHARM BIOCH BEHAV, V31, P773
[5]  
DAOUST M, 1984, Alcohol, V1, P379, DOI 10.1016/0741-8329(84)90007-7
[6]   CHRONIC ANTIDEPRESSANT DRUG REGIMES AND FOOD AND WATER-INTAKE IN RATS [J].
DURCAN, MJ ;
MCWILLIAM, JR ;
CAMPBELL, IC ;
NEALE, MC ;
DUNN, G .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 30 (02) :299-302
[7]   DIFFERENCES IN RESPONSE TO THE AVERSIVE PROPERTIES OF ETHANOL IN RATS SELECTIVELY BRED FOR ORAL ETHANOL PREFERENCE [J].
FROEHLICH, JC ;
HARTS, J ;
LUMENG, L ;
LI, TK .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 31 (01) :215-222
[8]   FLUOXETINE - A SEROTONERGIC APPETITE-SUPPRESSANT DRUG [J].
FULLER, RW ;
WONG, DT .
DRUG DEVELOPMENT RESEARCH, 1989, 17 (01) :1-15
[9]   GENETIC AND ENVIRONMENTAL-FACTORS IN ETHANOL SELF-ADMINISTRATION [J].
GEORGE, FR .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (02) :379-384
[10]   EFFECTS OF SEROTONIN UPTAKE BLOCKADE ON FOOD, WATER, AND ETHANOL-CONSUMPTION IN RATS [J].
GILL, K ;
AMIT, MA ;
AMIT, Z .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1987, 11 (05) :444-449