OLEIC-ACID - A MEMBRANE FLUIDIZER OR FLUID WITHIN THE MEMBRANE

被引：46

作者：

WALKER, M

HADGRAFT, J

机构：

[1] UNIV WALES COLL CARDIFF, WELSH SCH PHARM, CARDIFF CF1 3XF, WALES

[2] SQUIBB DERM, DEESIDE CH5 2NU, CLWYD, WALES

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 71卷 / 1-2期

关键词：

OLEIC ACID; STRATUM CORNEUM; PENETRATION ENHANCER; INTERCELLULAR LIPID;

D O I：

10.1016/0378-5173(91)90078-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies have been conducted that propose a mechanism of action for the penetration enhancer oleic acid (OA). The normal intercellular lipid arrangement of the stratum corneum may be disrupted by the introduction of 'fluid-like OA channels' within the corneum lipids at physiological temperatures.

引用

页码：R1 / R4

页数：4

共 8 条

[1] OLEIC-ACID - ITS EFFECTS ON STRATUM-CORNEUM IN RELATION TO (TRANS)DERMAL DRUG DELIVERY [J].