ROLE OF INTERFERON-GAMMA IN EXPERIMENTAL GRAM-NEGATIVE SEPSIS

被引：85

作者：

SILVA, AT ^{[1
]}

COHEN, J ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT INFECT DIS & BACTERIOL,DU CANE RD,LONDON W12 0NN,ENGLAND

来源：

JOURNAL OF INFECTIOUS DISEASES | 1992年 / 166卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/infdis/166.2.331

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To study the role of interferon-gamma (IFN-gamma) in gram-negative shock, mortality was compared in mice receiving either a monoclonal antibody to IFN-gamma (H22) or an irrelevant monoclonal antibody (L2-3D9) before or after an LD90 dose of Escherichia coli O111:B4. H22 given either 1 h before or 0.5 h after bacterial challenge protected mice from death (mortality at 48 h, 28% vs. 83%, P < .001). Serum tumor necrosis factor-alpha (TNF-alpha) levels and bacterial counts in blood and organs (liver, spleen, heart, and brain) were similar in H22-treated animals and controls. The peak serum TNF-alpha levels were 95.7 +/- 16.4 ng/mL and 80.7 +/- 14.9 ng/mL in the H22 and control groups, respectively. These results indicate that IFN-gamma plays a significant role in the pathogenesis of gram-negative sepsis.

引用

页码：331 / 335

页数：5

共 22 条

[1] CHARACTERIZATION OF RECEPTORS FOR HUMAN-TUMOR NECROSIS FACTOR AND THEIR REGULATION BY GAMMA-INTERFERON [J].