FUNCTIONAL AND ANTIISCHEMIC EFFECTS OF LUTEOLIN-7-GLUCOSIDE IN ISOLATED RABBIT HEARTS

被引：20

作者：

RUMP, AFE

SCHUSSLER, M

ACAR, D

CORDES, A

THEISOHN, M

ROSEN, R

KLAUS, W

FRICKE, U

机构：

[1] Institut für Pharmakologie, Universität Köln, Gleuelerstr. 24, Lindenthal

来源：

GENERAL PHARMACOLOGY | 1994年 / 25卷 / 06期

关键词：

NADH-FLUORESCENCE; MYOCARDIAL ISCHEMIA; CARDIOPROTECTION; PHOSPHODIESTERASE-INHIBITORS; ANTIOXIDANTS; FLAVONOIDS; LUTEOLIN-7-GLUCOSIDE;

D O I：

10.1016/0306-3623(94)90129-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The functional effects of the flavonoid luteolin-7-glucoside (LUT) were investigated in Langendorff-rabbit hearts perfused at constant pressure. Repetitive myocardial ischemia was induced by coronary artery ligature and quantified from NADH-fluorescence photography. 2. LUT significantly enhanced left ventricular pressure and the global and relative coronary flow (= global coronary flow/pressure - rate product). 3. LUT significantly diminished epicardial NADH-fluorescence area and intensity. 4. LUT is an inodilator possessing cardioprotective properties. These might be related to an improvement of myocardial perfusion and/or to free radical scavenging properties.

引用

页码：1137 / 1142

页数：6

共 36 条

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