ULTRAVIOLET-B EFFECTS ON OCULAR-TISSUES

被引：23

作者：

BABU, V ^{[1
]}

MISRA, RB ^{[1
]}

JOSHI, PC ^{[1
]}

机构：

[1] IND TOXICOL RES CTR,PHOTOBIOL LAB,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 210卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enhancement of UVB on the surface of the earth due to stratospheric ozone depletion may increase the risk of photochemically induced cataract. In this study, changes in the content of certain biological parameters were used as a marker to study ocular toxicity. A significant enhancement in the level of H2O2 LP and Pi, along with the depletion of GSH (antioxidant-defence system) in serum, aqueous humor and lens of albino mice exposed to UVB was observed. The level of Ca++ increased in serum and aqueous humor but decreased considerably in the lens due to increase in UVB exposure. These observations provide further clues to support the involvement of oxidative stress and Ca++ in the events leading to the formation of cataract. (C) 1995 Academic Press, Inc.

引用

页码：417 / 423

页数：7

共 29 条

[1]

Barber A A, 1967, Adv Gerontol Res, V2, P355

[2] EFFECTS OF DIFFUSIBLE PRODUCTS OF PEROXIDATION OF RAT-LIVER MICROSOMAL LIPIDS [J].

BENEDETTI, A ;

CASINI, AF ;

FERRALI, M ;

COMPORTI, M .

BIOCHEMICAL JOURNAL, 1979, 180 (02) :303-312

[3] MOLECULAR MECHANISM OF CATARACTOGENESIS .3. TOXIC METABOLITES OF OXYGEN AS INITIATORS OF LIPID-PEROXIDATION AND CATARACT [J].

BHUYAN, KC ;

BHUYAN, DK .

CURRENT EYE RESEARCH, 1984, 3 (01) :67-81

[4] DAMAGE TO MICROSOMAL MEMBRANE BY LIPID PEROXIDATION [J].

BIDLACK, WR ;

TAPPEL, AL .

LIPIDS, 1973, 8 (04) :177-182

[5] OCULAR HAZARDS ARISING FROM DEPLETION OF THE NATURAL ATMOSPHERIC OZONE-LAYER - A REVIEW [J].

CHARMAN, WN .

OPHTHALMIC AND PHYSIOLOGICAL OPTICS, 1990, 10 (04) :333-341

[6] THIOBARBITURIC ACID REACTION AND AUTOXIDATIONS OF POLYUNSATURATED FATTY ACID METHYL ESTERS [J].

DAHLE, LK ;

HILL, EG ;

HOLMAN, RT .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1962, 98 (02) :253-&

[7]

DAVID LL, 1984, INVEST OPHTH VIS SCI, V25, P1275

[8] SELECTIVE OXIDATION OF CYSTEINE AND METHIONINE IN NORMAL AND SENILE CATARACTOUS LENSES [J].

GARNER, MH ;

SPECTOR, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1274-1277

[9] A DIRECT CORRELATION BETWEEN THE LEVELS OF ASCORBIC-ACID AND H2O2 IN AQUEOUS-HUMOR [J].

GIBLIN, FJ ;

MCCREADY, JP ;

KODAMA, T ;

REDDY, VN .

EXPERIMENTAL EYE RESEARCH, 1984, 38 (01) :87-93

[10]

HIGHTOWER KR, 1982, INVEST OPHTH VIS SCI, V22, P263

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