TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA WITH INTERFERON-ALPHA AND INTERFERON-GAMMA

被引：7

作者：

KLOKE, O ^{[1
]}

MAY, D ^{[1
]}

WANDL, U ^{[1
]}

BECHER, R ^{[1
]}

OPALKA, B ^{[1
]}

BEER, U ^{[1
]}

NIEDERLE, N ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH,W GERMAN TUMOR CTR,DEPT MOLEC BIOL,W-4300 ESSEN 1,GERMANY

来源：

BLUT | 1990年 / 61卷 / 01期

关键词：

Chronic myelogenous leukemia; Interferon alpha; Interferon gamma;

D O I：

10.1007/BF01739433

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 23-year-old male patient with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) was treated with both IFN alpha and IFN gamma. Normalization of leukocyte counts was reached after 3 months of treatment. Southern blot analysis failed to detect the neoplastic cell clone after 19 months of therapy. Cytogenetically, complete suppression of Ph positive cells in the patient's bone marrow and blood was observed after 20 months and 25 months, respectively. This response was achieved with doses of IFN alpha and IFN gamma which were considerably lower than the dosage of IFN used in single agent therapy of CML. © 1990 Springer-Verlag.

引用

页码：45 / 46

页数：2