INDUCTION OF BETA-LACTAMASE PRODUCTION IN PSEUDOMONAS-AERUGINOSA BIOFILM

被引：116

作者：

GIWERCMAN, B

JENSEN, ET

HOIBY, N

KHARAZMI, A

COSTERTON, JW

机构：

[1] STATENS SERUM INST,DEPT CLIN MICROBIOL,DK-2300 COPENHAGEN,DENMARK

[2] UNIV CALGARY,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 05期

关键词：

D O I：

10.1128/AAC.35.5.1008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

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页码：1008 / 1010

页数：3

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