BLOOD-GROUP TYPE GLYCOSPHINGOLIPIDS OF HUMAN KIDNEYS - STRUCTURAL CHARACTERIZATION OF EXTENDED GLOBO-SERIES COMPOUNDS

被引：34

作者：

HOLGERSSON, J ^{[1
]}

JOVALL, PA ^{[1
]}

SAMUELSSON, BE ^{[1
]}

BREIMER, ME ^{[1
]}

机构：

[1] GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT SURG,S-41345 GOTHENBURG,SWEDEN

来源：

GLYCOCONJUGATE JOURNAL | 1991年 / 8卷 / 05期

关键词：

GLYCOLIPIDS; BLOOD GROUPS; HUMAN KIDNEY; MASS SPECTROMETRY; PROTON NMR SPECTROSCOPY;

D O I：

10.1007/BF00731294

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood group type glycosphingolipids present in kidneys of blood group A and B human individuals have been isolated and structurally characterized by mass spectrometry, proton NMR spectroscopy, degradation studies and by their reactivity with various monoclonal antibodies and Escherichia coli bacteria. The two major complex glycolipids present in the blood group A and B kidneys were globopentaosylceramide (IV3Gal-beta-Gb4Cer) and the X pentaglycosylceramide (III3Fuc-alpha-nLc4Cer). The major blood group A glycolipid in the blood group A kidneys was based on the type 4 chain (globo-series). There were also small amounts of the type 2 chain and trace amounts of the type 1 and type 3 chain based A glycolipids. In addition, the blood group H type 4 chain structure was present together with Le(a) and Le(b) compounds. In the blood group B kidneys, the major B glycolipids were monofucosylated hexa- and octaglycosylceramides, where the former were based on the type 2 carbohydrate chain. The blood group B type 4 chain heptaglycosylceramide was found to be a minor component making up only about 1% of the total blood group B structures.

引用

页码：424 / 433

页数：10

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