STUDIES ON THE PRIMARY SEQUENCE REQUIREMENTS FOR PKC-ALPHA, PKC-BETA-1 AND PKC-GAMMA PEPTIDE-SUBSTRATES

被引：47

作者：

MARAIS, RM ^{[1
]}

NGUYEN, O ^{[1
]}

WOODGETT, JR ^{[1
]}

PARKER, PJ ^{[1
]}

机构：

[1] LUDWIG INST CANC RES,LONDON W1P 8BT,ENGLAND

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

PROTEIN KINASE-C; KINASE SPECIFICITY; SYNTHETIC PEPTIDE;

D O I：

10.1016/0014-5793(90)80831-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The substrate specificity of purified PKC-alpha, -beta and -gamma has been investigated. A series of synthetic peptides based upon the sequence surrounding serine-7 in glycogen synthase were generated and used to determine the basic residue requirements of these PKC isotypes. While PKC-alpha and -beta are indistinguishable in their phosphorylation of these peptides, PKC-gamma shows a distinct specificity profile for these synthetic substrates.

引用

页码：151 / 155

页数：5

共 15 条

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