ACUTE PHYSICAL-DEPENDENCE IN HUMANS - REPEATED NALOXONE-PRECIPITATED WITHDRAWAL AFTER A SINGLE DOSE OF METHADONE

被引：23

作者：

WRIGHT, C ^{[1
]}

BIGELOW, GE ^{[1
]}

STITZER, ML ^{[1
]}

LIEBSON, IA ^{[1
]}

机构：

[1] FRANCIS SCOTT KEY MED CTR,BALTIMORE,MD

来源：

DRUG AND ALCOHOL DEPENDENCE | 1991年 / 27卷 / 02期

关键词：

PHYSICAL DEPENDENCE; METHADONE; NALOXONE; TIME COURSE; HUMANS;

D O I：

10.1016/0376-8716(91)90033-U

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This paper reports the intensity and duration of acute physical dependence precipitated by naloxone administration following a single pre-treatment with the opioid agonist methadone (30 mg/70 kg, i.m.) in six non-dependent human volunteers with histories of prior opioid abuse. In a within-subject cross-over design, challenges of the antagonist naloxone (0.5-1.0 mg, i.m.) were administered at 6, 30 and 54 h, 30 and 54 h, or at only 54 h after methadone pre-treatment. Acute physical dependence, as indicated by physiologic, subjective, and observer rated withdrawal, was seen in all subjects following active naloxone administration, was of nearly uniform intensity for a period of 6-54 h after acute methadone administration, and was not attenuated by prior naloxone administration.

引用

页码：139 / 148

页数：10

共 34 条

[1] EFFECTS OF NALOXONE AND NALORPHINE DURING DEVELOPMENT OF MORPHINE-DEPENDENCE IN RHESUS-MONKEYS [J].